This review article focuses on the top curcumin supplements made with Longvida’s unique curcumin extract formula.
Longvida® has demonstrated promising results in a growing number of clinical research trials testing it for potential health benefits.
All four brands featured in this article contain at least the same daily dose as those used in many of the clinical trials where Longvida proved itself effective.
Best Longvida Optimized Curcumin brands
Science resources included
As is my custom here on heydayDo, I will provide links to all of the relevant sports science & medical resources, clinical studies, and nutritional data used in this article.
For the product review portion of the article I will share the following important bits of info about each of the brands:
- Current cost per month
- Manufacturing quality standards
- Buyer ratings
Longvida’s medical evidence
In addition to combing over the supplements’ details, I will also talk a little about what clinical research has found out about Longvida:
- areas where Longvida offers benefits to us;
- what sets Longvida apart from typical curcumin products & other curcumin extract formulas.
Since the supplement companies featured in this article don’t own or make Longvida themselves, I thought it would be cool to provide some background on who these brands get their Longvida from, how the curcumin is sourced, etc.
And since the company that supplies these supplement makers their Longvida doesn’t own the patent to Longvida (they license it)…
…I’ll share a little information about the original invention of this unique curcumin extract formula itself, back before it even had the name Longvida associated with it.
Longvida® Optimized Curcumin Extract
*This allows for a much lower dose of curcumin to be used than the typical enhanced absorption curcumin extracts on the market.
*The dose of 400 mg Longvida (which has 80 mg curcumin in it) has demonstrated positive results in many research studies focusing on a variety of health conditions:
- Alzheimer’s disease (A)
- Cognitive function in healthy adults (B)
- Inflammation (C)
- Endothelial (heart & blood vessel) function (D)
- Exercise-induced muscle damage (E)
- Osteoarthritic knee pain (F)
The blue letters are links to a relevant clinical trial for their respective health issues, and open in a separate tab.
And there are several more Longvida studies, which you can find by searching the U.S. National Library of Medicine by clicking on its link.
You can also access a number of those studies, medical conference presentations, & preclinical papers on Longvida at Verdure Science’s Longvida research page.
Longvida®’s special & powerful sauce
For a quick introduction to Longvida, you can check out this 90-second video from Verdure Sciences, the people who make it:
I’ve called Longvida’s formula “unique” a couple of times already for good reason, as its effectiveness at low curcumin dosage levels is special amongst turmeric supplements.
But there’s something even bigger than that that Longvida has shown it can do that other turmeric supplements have not:
Bottom line, Longvida is (to my meager knowledge) one of the few (if not the only) turmeric curcumin extract formula that has repeatedly proven in legitimate clinical studies that it’s able to cross the blood-brain barrier**.
And I think this factor could be real important to keep in mind if you’re considering a candidate for your turmeric curcumin supplementation, particularly if you’re an older adult like yours truly over here.
**Um, blood-brain barrier?
I get that you may or may not understand what that information implies, depending on your knowledge of how curcumin goes to work (or tries to) in our bodies.
And you may not even know what the heck the blood-brain barrier is, or what role it plays in all this.
Don’t sweat it, we’ll ease into all that.
To kick things off, here’s another quick (2-minute) vid that’s easy-to-understand, on the important role of the blood-brain barrier.
So now you know why we as humans need the blood-brain barrier, but what does this have to do with Longvida® & other turmeric curcumin supplements?
The blood-brain barrier blocks curcumin
So while it’s keeping out the bad guys, our blood-brain barrier also won’t let curcumin’s beneficial compounds (curcuminoids) into our brain to do their restorative work.
But Longvida’s formula helps the curcumin pass through the blood-brain barrier, unlike other turmeric supplements.
There’s absorption & then there’s bioavailability
That is an important distinction to keep in mind.
There are several high-quality supplement products that get around curcumin’s poor absorption problem, by using an enhancer like black pepper extract.
I know this because I wrote about them here, after ploughing through 25+ brands looking for well-made, absorption-enhanced turmeric supplements.
But absorption in the gut does not mean guaranteed bioavailability in the brain.
So those enhanced turmeric extract supplements can work great for arthritis, inflammation, oxidative stress, & more for sure; clinical research has demonstrated that many times over.
But can they do the same as a Longvida-based supplement — meaning, cross the blood-brain barrier — and potentially provide benefit for our memory & cognitive functions upstairs in our noggin?
I don’t know since I’m not an expert, just a regular dude pokin’ around trying to find gems of truth amongst all the marketing smoke.
In any event, Longvida continues to be studied & tested:
“Longvida is backed by more than thirty published clinical trials with extensive research underway.” (1)
That’s another one of the real kickers for me, since I can think of only one other curcumin extract formula that has that much research backing it (BCM-95).
Longvida & the BBB (blood-brain barrier)
In the meantime, here is a video from Longvida licensee & manufacturer Verdure Sciences that interviews the lead investigator on a significant curcumin brain study, done at Ohio State University, talking about what he found while testing Longvida.
By the way…
…It just so happens that the 4 brands of supplements in this article using Longvida’s Optimized Curcumin have the same daily dose (or slightly higher) as was used in Dr. DiSilvestro’s clinical trial (400 mg of Longvida, yielding 80 mg of curcumin):
This makes a strong claim that these products are likely some of the best turmeric curcumin supplements around for anyone who’s interested in maintaining optimum brain function as they age.
I’m 61, and I guarantee you I want nothing to do with any cognitive decline, let alone any Alzheimer’s or dementia crap.
So I for one am plenty interested in “maintaining optimum brain function” 😄 .
Pre-review prep: What’s in Longvida?
Obviously Longvida has curcumin in it, but there are other things in its formula too.
After all, it’s a 400 mg Longvida dose but it only has 80 mg of curcumin in it.
In fact it’s some of the other ingredients in it that allow it to have the superior degree of absorption & bioavailability compared to plain curcumin & even other “enhanced” curcumin extract formulas.
Let’s see what all’s in Longvida, and you’ll see these same ingredients listed on the Supplement Facts label for any product that has Longvida in it.
Longvida’s other ingredients
- Vegetable cellulose (the capsule)
- Soy or sunflower lecithin
- Maltodextrin or rice flour
- Stearic acid
- Ascorbyl palmitate
Review of Longvida Optimized Curcumin products
So here are what I currently think are the four best Longvida-based curcumin extract supplements on the market.
Excluded a few competitors
I found a handful of other curcumin products that were also made with Longvida, but after looking into their products & their companies I excluded them for different reasons.
At the end of the day, I felt that they just weren’t on par with the four brands I selected for this article.
Product review categories
I’ll briefly go over each curcumin product separately, & here again are the areas I’ll touch on:
- Ingredients / Supplement Facts
- Manufacturing quality standards
- Buyer ratings
- I’ll prepare a monthly cost comparison table showing all four of them side by side too.
The curcumin supplements are listed from the one with the highest buyer ratings on down, and I compiled the reviews from as many online retailers I could find for each of them.
The % you see represents the percentage of reviewers who gave the product 4 or 5 stars.
To read buyer reviews or see current price on Amazon, click the product name or its pic — though CurcuminMD Plus has links to both Amazon & the 1MD website, since it’s so much cheaper there.
4.7 ⭐ – 90%, 350+ online ratings
*Pure Longvida product
*Serving size matches dose used for several successful studies (400 mg)
*Vegan, dairy-free, egg-free, Kosher, gluten-free, non-GMO, nut-free
*NOW has been in business since 1968 and is an American, family-owned company
4.7 ⭐ – 89%, 800+ online ratings
*I wrote an in-depth review of this CurcuminMD Plus product & the company that sell it (1MD) that you can read here on heydayDo.
*CurcuminMD Plus also has Boswellia Serrata extract in it, which has been clinically proven to be effective against osteoarthritis & inflammation. (3)
By the way/In case you didn’t know — Boswellia is the tree that frankincense comes from.
*The Longvida serving size matches dose used for several successful studies (400 mg)
$$ Tip > Below you’ll find CurcuminMD’s link to Amazon, where you can check current price.
But if you decide to buy this, just know that the Amazon price is a lot more than what 1MD will charge you on their website.
*Gluten-free, vegan, non-GMO, soy-free (uses sunflower lecithin instead of the usual soy lecithin)
*GMP (Good Manufacturing Practices) certified
*1MD is a Southern California-based company affiliated with doctors who put together its formulas
4.6 ⭐ – 88%, 470+ online ratings
*Pure Longvida product
*Serving size of 500 mg Longvida/115 mg curcumin is slightly higher dose than that used for several successful studies (400 mg/80 mg)
*Free from dairy, gluten, lactose, wheat, yeast, artificial flavors & colors, non-GMO, Kosher & Halal approved, vegan
*GMP certification in the UK
*Family-owned, nutrition science-based supplement company in Cambridge, England
4.4 ⭐ – 82%, 500+ online ratings
*Interestingly/oddly, their suggested serving size is 2 capsules to provide 1000 mg of Longvida.
This is more than double the dosages used (400 mg/day) in several of the Longvida clinical research trials I read.
An arthritis study using the high dose
But I did see a study using patients with chronic osteoarthritis who were given the 400 mg dose twice a day, while comparing them to patients receiving 400 mg of ibuprofen. (2)
The patients taking the Longvida had very similar pain-reduction results as those taking the NSAID ibuprofen.
In any event…
This 1000 mg dose is two capsules’ worth, so you can cut your cost in half & still take more than the proven effective dose by simply taking one pill a day instead of two. 😉
*Free from sugar, wheat, gluten, wheat, egg, salt, artificial colors & preservatives
*30+ year-old American company based in Southern California, with a focus on Chronic Fatigue Syndrome, Lyme Disease, & Fibromyalgia
*ProHealth has several quality standard certifications, & here’s a screenshot of their badges:
NSF-certified: The National Sanitation Foundation (NSF) is an independent (third-party) testing organization that verifies product purity & potency, as well as certifies the manufacturing facility to meet or exceed public health standards.
Cost comparison of Longvida products
For this comparison between the monthly cost of each of these curcumin extract supplements, I’m using the prices I see on Amazon today.
CHECK CURRENT PRICES >> Since online prices change quite often these days, at least in my health & fitness world — you’ll likely see different prices when you check them out. The supplement market is super-competitive, especially with hyped-up products like turmeric curcumin.
Ducks in a row
To get all four of these Longvida products aligned in an apples-to-apples lineup for the sake of cost comparing them, I had to make a couple of assumptions since there are 3 different daily doses between them…look:
- NOW 400 mg of Longvida
- Igennus 500 mg
- ProHealth 1000 mg
- 1MD 400 mg
Note: ProHealth sells their Longvida in a handful of different quantities & doses. I’m going with the version that I provided links for when I reviewed it a bit ago.
Assumption #1 – Split ProHealth dose in two
*I’m cutting ProHealth’s suggested dose in half, down to 500 mg per day.
This lines them up better with the other three brands.
I’m not sure why ProHealth is recommending a daily maintenance dose that’s double the clinically-effective dose anyways, so I’m comfortable doing this.
Plus it makes them 50% cheaper, since the bottle will last twice as long.
Assumption #2 – Consider 400 mg & 500 mg as the same
*These “Longvidas” are capsules of powder that aren’t easily opened & split into fractional doses.
I’m assuming nobody’s going to try & measure out that extra 100 mg every day just to save a buck or two every month…taking 400 mg of dry curcumin powder every 5 days is no picnic either.
So I’m not going to do the extra math to make the 400 mg & 500 mg daily cost line up exactly.
Here’s how these Longvida curcumin products look cost-per-month-wise using Amazon’s prices:
Wow, now there’s a huge price range amongst these four Longvida products, using Amazon’s prices**.
The cheapest contender to NOW’s CurcuBrain at $12.32 a month is ProHealth, and at $15.75 they’re still 25% more expensive.
** “Amazon’s prices” – important note
1MD’s CurcuminMD Plus costs up to $18 less a bottle on their website compared to the Amazon price, which you can verify by taking a peek at it here.
The missus & I went there and bought 6 months’ worth (apiece) several weeks ago, and paid in the neighborhood of 25 bucks a bottle…which is almost $20 less a bottle compared to Amazon’s price.
The one drag about the transaction I didn’t like was getting hammered by promo pages for other products of theirs once I hit the Checkout button.
How that went down
We had both been taking another enhanced-absorption turmeric extract, which had helped me & my overused joints immensely but hadn’t worked in an arthritic problem area of hers.
I discovered Longvida this year while doing curcumin research for articles here on heydayDo, and shared the existing clinical studies with her.
(She’s worked on human clinical trial research on cancer & infectious diseases for over 30 years, and is a Registered Nurse since 1975.)
So when she told me about Boswellia’s results with osteoarthritis patients, we went with 1MD’s CurcuminMD Plus.
Bottom line on Longvida product cost
*Understand that Longvida is Longvida, meaning there’s only one version of it.
*All of the companies in this article have high-quality certifications of their products’ purity & potency, as well as for their manufacturing standards.
*I bought the CurcuminMD Plus for its Boswellia because the wife had a bum hip joint recently turn up.
(Plus she told me to.)
Here are a few more fun facts about how good Longvida is…
Where is Longvida’s curcumin sourced from?
Verdure Sciences has the only license (that I’m aware of anyway) to manufacture the formula they call Longvida.
(I explain later who owns the recipe and in turn licenses its use to Verdure Sciences.)
The supplement companies featured in this article buy the Longvida powdered extract from Verdure, then they each manufacture their own Longvida product — three of them here in the U.S. and Igennus being in the UK has theirs made in Europe.
And all of the other supplement makers that use Longvida that I came across get theirs from Verdure Sciences too.
Longvida curcumin’s from Indian turmeric
And Verdure Sciences gets their curcumin from India, but that should not come as too much of a surprise to anyone real familiar with turmeric powder & its prevalence in Indian cooking.
Being a giant multinational conglomerate myself 😜, I happen to have global turmeric export data ranked by country handy…so let me share that with you.
India’s #1 in the world by a mile
What you see in the chart below are the Top 10 turmeric exporters ranked by dollars, though good luck finding #10.
Care to guess which country is responsible for almost 80% of the world’s turmeric?
How Verdure Sciences gets their turmeric
Here’s a short video from Longvida manufacturer Verdure Sciences showing how & where they contract their curcumin supply from Indian turmeric growers.
They also have a little bit on how it goes from a plant to a powder too.
A little dose of Longvida science
Here are a few bullet points’ worth of Longvida facts.
*SLCP® technology powers Longvida’s success
SLCP stands for Solid Lipid Curcumin Particles.
And as my simple brain understands it, by wrapping the active curcumin compounds in fat molecules (lipids) they can get through the digestive system without getting “tagged” and then excreted. (4)
This type of “free-form curcumin” is the only form that has been proven to then be able to cross the blood-brain barrier. (5)
*Bioavailability up to 285x greater
The huge increase in bioavailability over regular curcumin that Longvida has allows it to be clinically effective at a much lower dose than typical curcumin products.
This means it’s a very cost effective way to take advantage of curcumin’s main health benefits:
- Promote healthy aging
- Improve brain function
Regular curcumin gets glucuronidated…what?!
That long word up there that starts with a ‘g’ that I’m having a hard time pronouncing (no, not “gets” 😄) describes a common metabolism process our body does to rid itself of foreign substances like drugs, chemicals, & even bioactive things like curcumin.
It’s like a self-regulating, self-healing process where our bodies make glucuronic acid to rapidly break down those foreign things and literally flush them out of our system.
Great for bad stuff, bad for good stuff like curcumin.
Curcumin simply does not get absorbed well
Regular curcumin products have been proven time & time again to have extremely poor bioavailability (meaning, make it into our bloodstream so they can give us benefit). (6)
Ironically, as more studies continue to demonstrate poor bioavailability of curcumin, turmeric products explode onto the scene & are multiplying like rabbits on retailer shelves:
Longvida gets free curcumin into our bloodstream
Longvida’s unique SLCP “transport system” I described earlier helps the curcumin inside it to avoid glucuronidation, & instead become free curcumin —meaning it’s free to enter the bloodstream, cross the blood-brain barrier, all that…
…basically go where it wants to & do its thing.
From Verdure Sciences, who have been granted the license to produce Longvida by its patent owners:
“Throughout Longvida’s decade-long history, more than thirty human clinical trials have been published in support of the delivery of free curcumin.” (7)
Here’s a nice explanation of how the science behind Longvida distinguishes it from typical curcumin extract products, courtesy of Igennus, who’s supplement we looked at earlier:
A short story on Longvida
The supplement brands featured in this article each make their own curcumin product using Longvida®, but none of them own the rights to its intellectual property.
For example — Longvida® is not a 1MD product, CurcuminMD Plus is their product and Longvida is the unique curcumin extract they use in it.
But 1MD doesn’t make the Longvida themselves; again, they just make their own supplements and CurcuminMD Plus is one of those supplements.
Who makes Longvida?
Longvida® is made by Verdure Sciences, a very interesting & well-run company I stumbled upon when doing research on the different turmeric curcumin formulas that are in the supplements we’re getting flooded with these days.
But Verdure Sciences didn’t invent Longvida, nor do they own its patent, though they no doubt had a hand in giving it its name.
Who owns Longvida?
Longvida® is licensed to Verdure Sciences by the joint owners of its intellectual property & patent, the Regents of the University of California and the Department of Veteran Affairs in Washington, D.C. (8)
But (perhaps obviously)…
…the governing board of the ten colleges within the U.C. system didn’t take a break one day from their meetings about budgets & admission policies to go invent a groundbreaking chemical formula made from something inside the roots of a turmeric plant.
Who invented Longvida?
Longvida® was invented by two Ph.D’s working in the Department of Neurology at the David Geffen School of Medicine at UCLA:
The patent was filed by Dr.’s Frautschy & Cole in March 2007, and as mentioned was filed on behalf of the UC Regents & Veteran Affairs Dept.
Here’s a link to their original filing: US Patent Office
It was granted a few years later, thus distinguishing its formula as unique compared to all other curcumin extract formulas.
U.S. Patent: 9,192,644
Here’s something cool, if you’re into digging up old info like I am.
It’s the description & abstract submitted to the U.S. Patent Office back in 2007, when Sally Frautschy & Greg Cole originally filed the patent for the formula they invented…
…that eventually was named Longvida.
Bioavailable curcuminoid formulations for treating Alzheimer’s disease and other age-related disorders.
Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor.
A method of treating Alzheimer’s and other age-related diseases by administering such a composition is also provided.”
Related curcumin articles here on heydayDo
I hope that my article on the current best Longvida® Optimized Curcumin products is useful to you, and that the info on the science & company behind Longvida is helpful too.
I wish you well on your fitness journey.